Publications

Low protease activity in B cell follicles promotes retention of intact antigens after immunization
Aereas Aung, Ang Cui, Laura Maiorino, Ava P. Amini, Justin R. Gregory, Maurice Bukenya, Yiming Zhang, Heya Lee, Christopher A. Cottrell, Duncan M. Morgan, Murillo Silva, Heikyung Suh, Jesse D. Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Leah M. Froehle, Shuhao Xiao, Wuhbet Abraham, Josetta Adams, J. Christopher Love, Phillip Huyett, Douglas S. Kwon, Nir Hacohen, William R. Schief, Sangeeta N. Bhatia, Darrell J. Irvine
Science (2023)
Manuscript (PDF)

Cancer nanomedicine
Sangeeta N. Bhatia , Xiaoyuan Chen , Marina A. Dobrovolskaia and Twan Lammers
Nature Cancer Reviews (2022)
Manuscript (PDF)

Multiscale profiling of protease activity in cancer
Ava P. Amini, Jesse D. Kirkpatrick, Cathy S. Wang, Alex M. Jaeger, Susan Su, Santiago Naranjo, Qian Zhong, Christina M. Cabana, Tyler Jacks & Sangeeta N. Bhatia
Nature Communications (2022)
Manuscript (PDF)

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes
Whitney A. Scoon, Liliana Mancio-Silva, Ellen L. Suder, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, John G. Bernbaum, Steve Mazur, Reed F. Johnson, Judith Olejnik, Elizabeth Y. Flores, Aditya Mithal, Feiya Wang, Adam J. Hume, Joseph E. Kaserman, Sandra March-Riera, Andrew A. Wilson, Sangeeta N. Bhatia, Elke Mühlberger, Gustavo Mostoslavsky
Cell Reports (2022)
Manuscript (PDF)

Conditional Antimicrobial Peptide Therapeutics
Chayanon Ngambenjawong, Leslie W. Chan, Heather E. Fleming, and Sangeeta N. Bhatia
ACS Nano (2022)
Manuscript (PDF)

Direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer
Guinevere G. Connelly, Orville O. Kirkland, Seven Bohannon, Daniel C. Lim, Robert M. Wilson, Edward J. Richards, Dousabel M. Tay, Hyuk Jee, Riley D. Hellinger, Ngoc K. Hoang, Liang Hao, Arnav Chhabra, Carmen Martin-Alonso, Edward K.W. Tan, Angela N. Koehler, Michael B. Yaffe, Wendy B. London, Pui Y. Lee, Florian Krammer, Robert C. Bohannon, Sangeeta N. Bhatia, Hadley D. Sikes, Hojun Li
Cell Reports Methods(2022)
Manuscript (PDF)

Protease Activity Analysis: A Toolkit for Analyzing Enzyme Activity Data
Ava P. Soleimany, Carmen Martin-Alonso, Melodi Anahtar, Cathy S. Wang, and Sangeeta N. Bhatia
ACS(2022)
Manuscript (PDF)

A vascularized model of the human liver mimics regenerative responses
Arnav Chhabra, H.-H. Greco Song, Katarzyna A. Grzelak, William J. Polacheck, Heather E. Fleming, Christopher S. Chen, and Sangeeta N. Bhatia
PNAS(2022)
Manuscript (PDF)

Host protease activity classifies pneumonia etiology
Melodi Anahtar, Leslie W. Chan, Henry Ko, Aditya Rao, Ava P. Soleimany, Purvesh Khatri, and Sangeeta N. Bhatia
PNAS(2022)
Manuscript (PDF)

A single-cell liver atlas of Plasmodium vivax infection
Liliana Mancio-Silva, Nil Gural, Eliana Real, Marc H. Wadsworth II, Vincent L. Butty, Sandra March, Niketa Nerurkar, Travis K. Hughes, Wanlapa Roobsoong, Heather E. Fleming, Charlie A. Whittaker, Stuart S. Levine, Jetsumon Sattabongkot, Alex K. Shalek, and Sangeeta N. Bhatia
Cell Host & Microbe (2022)
Manuscript (PDF)

Early detection of cancer
David Crosby, Sangeeta Bhatia, Kevin M. Brindle, Lisa M. Coussens, Caroline Dive, Mark Emberton, Sadik Esener, Rebecca C. Fitzgerald, Sanjiv S. Gambhir†, Peter Kuhn, Timothy R. Rebbeck, Shankar Balasubramanian
Science (2022)
Manuscript (PDF)

Ionic Liquid-Mediated Transdermal Delivery ofThrombosis-Detecting Nanosensors
Ahmet Bekdemir, Eden E. L. Tanner, Jesse Kirkpatrick, Ava P. Soleimany, Samir Mitragotri, and Sangeeta N. Bhatia
Advanced Healthcare Materials (2022)
Manuscript (PDF)

Distinct Hepatic Gene-Expression Patterns of NAFLD in Patients With Obesity
Sonu Subudhi, Hannah K. Drescher, Laura E. Dichtel, Lea M. Bartsch, Raymond T. Chung, Matthew M. Hutter, Denise W. Gee, Ozanan R. Meireles, Elan R. Witkowski, Louis Gelrud, Ricard Masia, Stephanie A. Osganian, Jenna L. Gustafson, Steve Rwema, Miriam A. Bredella, Sangeeta N. Bhatia, Andrew Warren, Karen K. Miller, Georg M. Lauer, Kathleen E. Corey
Hepatology Communications (2022)
Manuscript (PDF)

Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds
Q. Smith, J. Bays, L. Li, H. Shareef, C. S. Chen, and S. N. Bhatia
Advanced Science (2021)
Manuscript (PDF)

Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors
S. C. Cazanave, A. D. Warren , M. Pacula , F. Touti , A. Zagorska, N. Gural, E. K. Huang , S. Sherman, M. Cheema , S. Ibarra , J. Bates, A. N. Billin, J. T. Liles, G. R. Budas, D. G. Breckenridge , D. Tiniakos, V. Ratziu, A. K. Daly, O. Govaere , Q. M. Anstee, L. Gelrud, J. Luther, R. T. Chung, K. E. Corey , W. Winckler, S. Bhatia, G A. Kwong
Science Translational Medicine (2021)
Manuscript (PDF)

Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis
J. D. Kirkpatrick, A. P. Soleimany, J. S. Dudani, H-J Liu, H. C. Lam, C. Priolo, E. P. Henske, S. N. Bhatia
European Respiratory Journal (2021)
Manuscript (PDF)

Synthetic biomarkers: a twenty-first century path to early cancer detection
G. A. Kwong, S. Ghosh, L. Gamboa, C. Patriotis, S. Srivastava and S. N. Bhatia
Nature Reviews Cancer (2021)
Manuscript (PDF)

Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function
A.G. Schepers, J. Shan, A. G. Cox, A. Huang, H. Evans, C. Walesky, H. E. Fleming, W. Goessling, and S. N. Bhatia
ACS Chemical Biology (2021)
Manuscript (PDF)

Synthetic Circuit-Driven Expression of Heterologous Enzymes for Disease Detection
J. He, L. Nissim, A. P. Soleimany, A. Binder-Nissim, H. E. Fleming, T. K. Lu, S. N. Bhatia
ACS Synthetic Biology (2021)
Manuscript (PDF)

Evidential Deep Learning for Guided Molecular Property Prediction and Discovery
A.P. Soleimany, A. Amini, S. Goldman, D. Rus, S.N. Bhatia, and C.W. Coley
ACS Central Science (2021)
Manuscript (PDF)