Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses

Sandra March, Niketa Nerurkar, Anisha Jain, Linda Andrus, Daniel Kim, Charles A. Whittaker, Edward K.W. Tan, Sabine Thiberge, Heather E. Fleming, Liliana Mancio-Silva, Charles M. Rice, and Sangeeta N. Bhatia.

Science Advances (2024)

Manuscript: (PDF)

News coverage:

MIT News Feature (here), AAAS Feature (here).

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Improving drug discovery by nucleic acid delivery in engineered human microlivers

L. Mancio-Silva, H. E. Fleming, A. B. Miller, S. Milstein, A. Liebow, P. Haslett, L. Sepp-Lorenzino, and S. N. Bhatia.
Cell Metabolism (2019)

Manuscript (PDF)