Publications
Image-guided injectable niche for hepatocyte transplantation
Vardhman Kumar, Joa Yun, Susanna K. Elledge, Nicole Henning, Katarzyna A. Grzelak, Ashley D. Westerfield, Amy Stoddard, Favour A. Oladimeji, Virginia Spanoudaki, Kasturi Chakraborty, Savan K. Patel, Heather E. Fleming, Christopher S. Chen, Sangeeta N. Bhatia
Cell Biomaterials
Manuscript (PDF)
Mapping Plasmodium transitions and interactions in the Anopheles female
Yan Yan, Lisa H. Verzier, Elaine Cheung, Federico Appetecchia, Sandra March, Ailsa R. Craven, Esrah Du, Alexandra S. Probst, Tasneem A. Rinvee, Laura E. de Vries, Jamie Kauffman, Sangeeta N. Bhatia, Elisabeth Nelson, Naresh Singh, Duo Peng, W. Robert Shaw & Flaminia Catteruccia
Nature (2025)
Manuscript (PDF)
Towards Breath Based Diagnostics via Water-mediated Capture ofSynthetic Breath Biomarkers in SERS-active Plasmonic Nanogaps
Aditya Garg, Marissa Morales, Aashini Shah, Daniel Kim, Ming Lei, Sahil Patel, Jia Dong, Seleem Badawy, Sangeeta Bhatia, Loza F. Tadesse
BioRxiv (2026)
Manuscript (PDF)
Engineering a heparin-mimeticbiomaterial to promote tissue vascularization
Linqing Li, Jinling Yang, Luba Perry, Jennifer L. Bays, Sangeeta Bhatia, Jeroen Eyckmans & Christopher S. Chen
Communications Biology (2026)
Manuscript (PDF)
Molecular determinants of antibody-mediated priming to enhance detection of ctDNA
Shervin Tabrizi, Claire Sullivan, Kasturi Chakraborty Carmen Martin-Alonso, Zhenyi An, Lily Gao, Daniel M. Kim, Savan K. Patel, Timothy Blewett, Justin Rhoades, Ruolin Liu, Sahil Patel, Kan Xiong, Andjela Crnjac, Sangeeta N. Bhatia, Viktor A. Adalsteinsson, J. Christopher Love
BioRxIV(2026)
Manuscript (PDF)
Deep learning guided design of protease substrates
Carmen Martin-Alonso, Sarah Alamdari, Tahoura S. Samad, Kevin K. Yang, Sangeeta N. Bhatia & Ava P. Amini
Nature Communications (2026)
Manuscript (PDF)
Microbial-inspired antidotes to repurpose toxic compounds as antibiotics
Tahoura Samad, Chayanon Ngambenjawong, Henry Ko, Savan Patel, Cristiana DeAgazio, Heather E. Fleming, Sangeeta N. Bhatia
BioRxiv (2025)
Manuscript (PDF)
Synthetic Control of Implanted Engineered Liver Tissue Growth
Amy E. Stoddard, Vardhman Kumar, Constantine N. Tzouanas, Veronica Hui, Jeffrey Li, Anisha Jain, Alanna Farrell, Sangeeta N. Bhatia, Christopher S.
BioRxiv (2025)
Manuscript (PDF)
Electrical stimulation directs formation of perfused vasculature in engineered tissues
Katarzyna A. Grzelak, Ashley D. Westerfield, Vardhman Kumar, Kasturi Chakraborty, Navaneeth Krishna Rajeeva Pandian, Christopher S. Chen, Sangeeta N. Bhatia
bioRxiv (2025)
Manuscript (PDF)
A 3D in vitro model of the human hepatobiliary junction
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton-Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia
bioRxiv (2025)
Manuscript (PDF)
Scar-associated endothelial-stellate cellular crosstalk drives fibrosis resolution in MASH
Kenneth Li, Vardhman Kumar, Tran To, Maylene Yu, Bruno Cogliati, Yashaswini N Chittampalli, Mark Miller, Andrea D Branch, Bruno Giotti, Alexander M Tsankov, Li Chen, Mathieu Petitjean, Chenggang Lu, Yang Li, Sangeeta N Bhatia, Scott L Friedman, Shuang Wang
bioRxiv (2025)
Manuscript (PDF)
Multimodal profiling of proinflammatory protease activity identifies caspase-1 as a target for lung cancer interception
Cathy S. Wang, Qian Zhong, Shih-Ting Wang, Carmen Martin-Alonso, Sofia Neaher, Sahil Patel, Tiziana Parisi, Jesse D. Kirkpatrick, Lecia V. Sequist, Tyler E. Jacks, Sangeeta N. Bhatia
bioRxiv (2025)
Manuscript (PDF)
Engineering multiplexed synthetic breath biomarkers as diagnostic probes
Wang, S-T., Anahtar, M., Kim, D.M., Samad, T.S., Zheng, C.M., Patel, S., Ko, H., Ngambenjawong, C., Wang, C.S., Kirkpatrick, J.D., Kumar, V., Fleming, H.E., and Bhatia, S.N.
bioRxiv (2024)
Manuscript (PDF)
Conditional fusogenic lipid nanocarriers for cytosolic delivery of macromolecular therapeutics
Zhong, Q., Tan, E.K., Shyamal, A., Ngambenjawong, C., Parisi, T., Ko, H., Fleming, H.E., Jacks, T., and Bhatia, S.N.
bioRxiv (2024)
Manuscript (PDF)
Expandable, functional hepatocytes derived from primary cells enable liver therapeutics
Mallanna, S.K., Karanth, S.S., Marturano, J.E., Kudva, A.K., Lehmann, M., Morse, J.K., Jamiel, M., Norman, T., Wilson, C., Munarin, F., Broderick, D., Van Buskirk, M., Uddin, E., Ret, M., Steele, C., Cheema, M., Black, J., Vanderploeg, E., Chen, C., Bhatia, S.N., Rezania, A., Lowery, T.J., Cazanave, S., and Chhabra, A.
bioRxiv (2024)
Manuscript (PDF)
Modulating cell-free DNA biology as the next frontier in liquid biopsies
Tabrizi, S., Martin-Alonso, C., Xiong, K., Bhatia, S.N.*, Adalsteinsson, V.A.*, and Love, C.J.*
Trends in Cell Biology (2025)
Manuscript (PDF)
Nanobody-targeted conditional antimicrobial therapeutics
Chayanon Ngambenjawong, Henry Ko, Tahoura Samad, Novalia Pishesha, Hidde L. Ploegh, and Sangeeta N. Bhatia
ACS Nano (2025)
Manuscript (PDF)
CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics
Van Heest AE, Deng F, Zhao RT, Harzallah NS, Fleming HE, Bhatia SN, Hao L.
JoVE (2023)
Manuscript (PDF)
Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA
Li B, Jiang AY, Raji I, Atyeo C, Raimondo TM, Gordon AGR, Rhym LH, Samad T, MacIsaac C, Witten J, Mughal H, Chicz TM, Xu Y, McNamara RP, Bhatia S, Alter G, Langer R, Anderson DG.
Nature Biomedical Engineering (2023)
Manuscript (PDF)