Publications
Electrical stimulation directs formation of perfused vasculature in engineered tissues
Katarzyna A. Grzelak, Ashley D. Westerfield, Vardhman Kumar, Kasturi Chakraborty, Navaneeth Krishna Rajeeva Pandian, Christopher S. Chen, Sangeeta N. Bhatia
bioRxiv (2025)
Manuscript (PDF)
A 3D in vitro model of the human hepatobiliary junction
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton-Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia
bioRxiv (2025)
Manuscript (PDF)
Scar-associated endothelial-stellate cellular crosstalk drives fibrosis resolution in MASH
Kenneth Li, Vardhman Kumar, Tran To, Maylene Yu, Bruno Cogliati, Yashaswini N Chittampalli, Mark Miller, Andrea D Branch, Bruno Giotti, Alexander M Tsankov, Li Chen, Mathieu Petitjean, Chenggang Lu, Yang Li, Sangeeta N Bhatia, Scott L Friedman, Shuang Wang
bioRxiv (2025)
Manuscript (PDF)
Deep learning guided design of protease substrates
Carmen Martin-Alonso, Sarah Alamdari, Tahoura S. Samad, Kevin K. Yang, Sangeeta N. Bhatia, Ava P. Amini
bioRxiv (2025)
Manuscript (PDF)
Multimodal profiling of proinflammatory protease activity identifies caspase-1 as a target for lung cancer interception
Cathy S. Wang, Qian Zhong, Shih-Ting Wang, Carmen Martin-Alonso, Sofia Neaher, Sahil Patel, Tiziana Parisi, Jesse D. Kirkpatrick, Lecia V. Sequist, Tyler E. Jacks, Sangeeta N. Bhatia
bioRxiv (2025)
Manuscript (PDF)
Engineering multiplexed synthetic breath biomarkers as diagnostic probes
Wang, S-T., Anahtar, M., Kim, D.M., Samad, T.S., Zheng, C.M., Patel, S., Ko, H., Ngambenjawong, C., Wang, C.S., Kirkpatrick, J.D., Kumar, V., Fleming, H.E., and Bhatia, S.N.
bioRxiv (2024)
Manuscript (PDF)
Conditional fusogenic lipid nanocarriers for cytosolic delivery of macromolecular therapeutics
Zhong, Q., Tan, E.K., Shyamal, A., Ngambenjawong, C., Parisi, T., Ko, H., Fleming, H.E., Jacks, T., and Bhatia, S.N.
bioRxiv (2024)
Manuscript (PDF)
Mapping Plasmodium transitions and interactions in the Anopheles female
Yan, Y., Cheung, E., Verzier, L.H., Appetecchia, F., March, S., Craven, A.R., Du, E., Probst, A.S., Rinvee, T.A., de Vries, L.E., Kauffman, J., Bhatia, S.N., Nelson, E., Singh, N., Peng, D., Shaw, W.R., and Catteruccia, F.
bioRxiv (2024)
Manuscript (PDF)
Expandable, functional hepatocytes derived from primary cells enable liver therapeutics
Mallanna, S.K., Karanth, S.S., Marturano, J.E., Kudva, A.K., Lehmann, M., Morse, J.K., Jamiel, M., Norman, T., Wilson, C., Munarin, F., Broderick, D., Van Buskirk, M., Uddin, E., Ret, M., Steele, C., Cheema, M., Black, J., Vanderploeg, E., Chen, C., Bhatia, S.N., Rezania, A., Lowery, T.J., Cazanave, S., and Chhabra, A.
bioRxiv (2024)
Manuscript (PDF)
Modulating cell-free DNA biology as the next frontier in liquid biopsies
Tabrizi, S., Martin-Alonso, C., Xiong, K., Bhatia, S.N.*, Adalsteinsson, V.A.*, and Love, C.J.*
Trends in Cell Biology (2025)
Manuscript (PDF)
Nanobody-targeted conditional antimicrobial therapeutics
Ngambenjawong, C., Ko, H., Pishesha, N., Ploegh, H. L., and Bhatia, S.N.
ACS Nano (2025)
Manuscript (PDF)
CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics
Van Heest AE, Deng F, Zhao RT, Harzallah NS, Fleming HE, Bhatia SN, Hao L.
JoVE (2023)
Manuscript (PDF)
Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA
Li B, Jiang AY, Raji I, Atyeo C, Raimondo TM, Gordon AGR, Rhym LH, Samad T, MacIsaac C, Witten J, Mughal H, Chicz TM, Xu Y, McNamara RP, Bhatia S, Alter G, Langer R, Anderson DG.
Nature Biomedical Engineering (2023)
Manuscript (PDF)
Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses
Sandra March, Niketa Nerurkar, Anisha Jain, Linda Andrus, Daniel Kim, Charles A. Whittaker, Edward K.W. Tan, Sabine Thiberge, Heather E. Fleming, Liliana Mancio-Silva, Charles M. Rice, and Sangeeta N. Bhatia.
Science Advances (2024)
Manuscript: (PDF)
News coverage:
Targeting and monitoring ovarian cancer invasion with an RNAi and peptide delivery system
Liangliang Hao, Natalie Boehnke, Susanna K. Elledge, Nour-Saïda Harzallah, Renee T. Zhao, Eva Cai, Yu-XiongFeng, Sofia Neaher, Heather E. Fleming, Piyush B. Gupta, Paula T. Hammond, and Sangeeta N. Bhatia.
PNAS (2024)
Manuscript: (PDF)
Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies
Carmen Martin-Alonso, Shervin Tabrizi , Kan Xiong, Timothy Blewett, Sainetra Sridhar, Andjela Crnjac, Sahil Patel, Zhenyi An, Ahmet Bekdemir, Douglas Shea, Shih-Ting Wang, Sergio Rodriguez-Aponte, Christopher A. Naranjo, Justin Rhoades, Jesse D. Kirkpatrick, Heather E. Fleming, Ava P. Amini, Todd R. Golub, J. Christopher Love , Sangeeta N. Bhatia, and Viktor A. Adalsteinsson.
Science (2024)
Manuscript (PDF)
Cited by:
Tina Moser, Ellen Heitzer, Surpassing sensitivity limits in liquid biopsy. Science383,260-261 (2024). (PDF).
Sarah Crunkhorn, Improving liquid biopsy for cancer detection. Nature Reviews Drug Discovery (2024). (PDF).
News coverage:
CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics
Liangliang Hao, Renee T. Zhao, Nicole L. Welch, Edward Kah Wei Tan, Qian Zhong, Nour Saida Harzallah, Chayanon Ngambenjawong, Henry Ko, Heather E. Fleming, Pardis C. Sabeti & Sangeeta N. Bhatia
Nature Nanotechnology (2023)
Manuscript (PDF)
